Yazar "Rollas, Sevim" için listeleme
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Importance and review of drug metabolite synthesis
Şahin, Zafer; Omurtag Özgen, Pınar Sinem; Rollas, Sevim (Istanbul University, 2023)Phase I and Phase II metabolic reactions are involved in the pharmacokinetic properties of drugs after administration. These reactions mainly aim to make drugs more polar and eliminate them safely. However, some of these ... -
Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivatives
Kandemir, Levent; Karakuş, Sevgi; Özbaş, Suna; Rollas, Sevim; Akbuğa, Julide (Marmara University, 2022)In this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide ...